Results were robust to sensitivity analyses. In time-to-event models, similar outcomes for bloodstream infection and catheter occlusion were noted however, the risk of DVT events was lower in patients who received PICCs vs midlines (hazard ratio, 0.53 95% CI, 0.38-0.74). 001) in midlines vs PICCs no significant difference in the risk of DVT between PICCs and midlines was observed. 001) and bloodstream infection (0.4% vs 1.6% P <. Reduction in complications stemmed from lower rates of occlusion (2.1% vs 7.0% P <. After adjusting for patient characteristics, comorbidities, catheter lumens, and dwell time in logit models, patients who received PICCs had a greater risk of developing a major complication compared with those who received midlines (odds ratio, 1.99 95% CI, 1.61-2.47). Sensitivity analyses limiting analyses to 10 days of device dwell were performed.ĭata on 10 863 patients, 5758 with PICCs and 5105 with midlines (median age of device recipients, 64.8 years 5741 were female), were included. Logistic regression and Cox proportional hazards regression models (taking into account catheter dwell) were used to estimate risk for major complications, adjusting for patient and device characteristics and the clustered nature of the data. Major complications, including a composite of symptomatic catheter-associated deep vein thrombosis (DVT), catheter-related bloodstream infection, and catheter occlusion. Data were analyzed from October 2020 to March 2021. This cohort study analyzed data from a multihospital registry including patients admitted to a participating site from December 2017 through January 2020 who had a PICC or midline placement for the indications of difficult venous access or intravenous antibiotic therapy prescribed for 30 or fewer days. To compare outcomes between patients who had a PICC vs midline placed for the indication of difficult vascular access or antibiotic therapy for 30 or fewer days. Peripherally inserted central catheters (PICCs) and midlines are frequently used for short-term venous access whether one is safer than the other in this setting has not been adequately reported.
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